Pizza Meatloaf Recipe

ByKimberly January 11, 2026January 11, 2026

If you love the comforting flavors of pizza but want a fun twist on the classic, this Pizza Meatloaf Recipe is an absolute winner. Combining the hearty goodness of a traditional meatloaf with the irresistible ingredients of a pizza, it’s a delicious crowd-pleaser that brings cheesy, savory, and zesty notes all in one. Perfect for weeknight dinners or casual get-togethers, this dish delivers a warm hug of flavor with every slice.

Ingredients You’ll Need

These ingredients might seem simple, but each one plays a crucial role in creating the perfect balance of taste, texture, and color in your Pizza Meatloaf Recipe. From the blend of meats to the spices and cheese, they work together to make this dish truly unforgettable.

1 lb ground beef (93% lean): The meaty base that keeps the loaf juicy but not greasy.
½ lb Italian sausage (casings removed): Adds a rich, garlicky depth that’s essential for that pizza flavor punch.
½ cup chopped pepperoni: Brings smoky, spicy bursts reminiscent of your favorite pie.
1 cup shredded mozzarella cheese: The cheesy glue that melts into every bite for ultimate gooeyness.
1 egg (slightly beaten): Helps bind all the ingredients together perfectly.
1 cup rolled oats (old fashioned): A wholesome filler that gives the loaf great texture without overpowering the flavors.
1 Tbsp Italian seasoning: A fragrant blend that ties all the herbs and spices beautifully.
1 tsp salt: Enhances all the natural flavors.
¼ tsp black pepper: Adds a gentle heat and depth.
¼ tsp garlic powder: Infuses that signature savory warmth.
¼ tsp onion powder: Balances with subtle sweetness and complexity.
¼ tsp dried oregano: Brings that earthy, classic pizza herb aroma.
¾ cup milk: Adds moisture, keeping the loaf tender.
1 cup pizza sauce: The tangy topping that seals the deal on this pizza-inspired meatloaf.

How to Make Pizza Meatloaf Recipe

Step 1: Preheat and Prepare

Start by preheating your oven to 400ºF. This high heat will give your meatloaf a nicely browned exterior while keeping the inside moist and tender.

Step 2: Combine the Meaty Mixture

In a large bowl, gently mix together the ground beef, Italian sausage, chopped pepperoni, mozzarella cheese, slightly beaten egg, rolled oats, Italian seasoning, salt, black pepper, garlic powder, onion powder, dried oregano, and milk. Take your time to combine everything evenly without overworking the meat, which keeps your meatloaf tender.

Step 3: Shape the Loaf

Press the meat mixture firmly into a 9×5-inch loaf pan or a dedicated meatloaf pan. Shaping it neatly ensures even cooking and gives your Pizza Meatloaf Recipe that classic loaf look.

Step 4: Add the Pizza Sauce

Spread a generous layer of pizza sauce over the top of the meat mixture. This sauce adds moisture, tang, and that unmistakable pizza vibe once baked.

Step 5: Bake Until Perfect

Place your meatloaf in the preheated oven and bake for 40 to 50 minutes, or until it feels firm to the touch and the internal temperature reaches a safe 160ºF. The aroma filling your kitchen will be pure magic.

How to Serve Pizza Meatloaf Recipe

Garnishes

A sprinkle of freshly chopped basil or a few torn basil leaves scattered on top add a bright, fresh taste that contrasts wonderfully with the rich meatloaf. If you like a touch of heat, red pepper flakes are a great option too.

Side Dishes

Keep it simple with a crisp green salad or roasted vegetables to balance the richness of the meatloaf. Garlic bread or cheesy breadsticks make a fun nod to classic pizza sides that everyone will enjoy alongside the main dish.

Creative Ways to Present

For a party, slice the meatloaf into thick pieces and serve as sliders with mini buns, adding some extra pizza sauce or ranch for dipping. You can even top each slice with a little extra mozzarella and broil briefly for melty, bubbly toppings that feel extra special.

Make Ahead and Storage

Storing Leftovers

Once cooled completely, wrap your leftover Pizza Meatloaf tightly in plastic wrap or foil and store it in an airtight container in the refrigerator. It will keep well for up to 4 days, making it a perfect next-day lunch or quick dinner fix.

Freezing

This recipe freezes beautifully! Wrap the cooled whole loaf or individual slices tightly before placing in a freezer-safe bag or container. For best quality, enjoy within 2 to 3 months. Thaw overnight in the fridge before reheating.

Reheating

To reheat, place slices in a warm oven at 350ºF for about 15 minutes, or until heated through. Cover with foil to keep it moist. Microwave works too for convenience, but the oven keeps that lovely texture intact.

FAQs

Can I use all ground beef, or do I need the Italian sausage?

You can absolutely use all ground beef if you prefer, but the Italian sausage brings authentic seasoning and fat content that enriches the flavor to perfectly mimic a pizza taste.

Is rolled oats the only binder I can use?

Rolled oats work wonderfully here for texture and binding, but you could substitute with breadcrumbs if that’s what you have on hand, though the flavor and moisture might vary slightly.

Can I make this Pizza Meatloaf Recipe ahead of time?

Yes! You can prepare the meat mixture and shape it in the loaf pan, then cover and refrigerate for a few hours before baking. It’s a big time saver on busy days.

What if I don’t have pizza sauce?

If pizza sauce isn’t available, marinara or even a robust tomato sauce works well as a topping, maintaining that tangy, herby finish.

How do I know when the meatloaf is cooked?

The best way is to check that the internal temperature reaches 160ºF using a meat thermometer. The meatloaf should also feel firm and the juices run clear.

Final Thoughts

This Pizza Meatloaf Recipe is the kind of comforting meal that feels both nostalgic and exciting. It’s a fantastic way to bring family and friends together over familiar but novel flavors. I encourage you to give it a try soon—you might just find yourself making it a weekly favorite!

Kimberly