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If you’ve ever craved a sandwich bursting with bold flavors, bright textures, and a satisfying bite, then you are in for a treat with this How to Make Italian Sub Sandwiches Recipe. This classic Italian sub combines savory Genoa salami, spicy pepperoni, tender roasted turkey, and rich Provolone with crunchy lettuce, tangy pickled banana peppers, and a zingy vinaigrette, all nestled inside a hearty Italian bread loaf. It’s an absolute delight that’s as perfect for a casual lunch as it is for impressing guests at a picnic or party. Let me walk you through every delicious step of bringing this iconic sandwich to life in your own kitchen!
Ingredients You’ll Need
Gathering the right ingredients is the first exciting step in any recipe, and this one is no different. Each component contributes something important—whether it’s the comforting softness of the bread, the savory zing of meats, or the crisp freshness of vegetables—making every bite a harmonious experience.
- Italian bread loaf: This will hold all your fillings together, providing a chewy yet sturdy base perfect for hearty sandwiches.
- Mayonnaise: Spread on the bread for a creamy texture that laces every bite with moisture and richness.
- Genoa salami: Adds a flavorful, slightly spicy cured meat element that’s essential to the Italian sub’s personality.
- Pepperoni: Brings a bit of zesty heat and a spicy depth as a perfect partner to the salami.
- Roasted turkey breast: Offers a lean, tender contrast that lightens the meat layer while keeping things satisfying.
- Semi-aged Provolone cheese: This cheese brings a sharp, slightly smoky note that binds the meats and adds richness.
- Chopped iceberg lettuce: Delivers a refreshing crunch and mild flavor that balances the richer ingredients.
- Chopped tomatoes: Juicy and sweet, these brighten the sandwich and add vibrant color.
- Pickled banana peppers (pepperoncini): Provide tangy, slightly sweet spice, cutting through the richness perfectly.
- Chopped Kalamata olives: Bring a salty, briny pop that enlivens each bite.
- Extra virgin olive oil: Drizzled over the veggies, it adds luscious smoothness and depth of flavor.
- Red wine vinegar: Offers acidity to brighten and enhance all the fresh ingredients.
- Dried Italian seasoning: A fragrant herb blend that ties all the flavors together beautifully.
How to Make How to Make Italian Sub Sandwiches Recipe
Step 1: Prepare the Bread Base
Start by slicing the large Italian loaf lengthwise with a serrated knife. Carefully hollow out some of the soft interior from the top half without breaking the bread’s structure. This gives you the perfect cavity for the fillings and prevents the sandwich from becoming too bulky or falling apart. Don’t toss that bread you scoop out—it makes fantastic breadcrumbs for other recipes!
Step 2: Add the Creamy Mayonnaise Layer
Spread 1/3 cup of mayonnaise evenly over the bottom half of the bread. This isn’t just about moisture; it creates a velvety cushion that helps keep the meats moist and adds a subtle richness that’s key to the sandwich’s indulgence factor.
Step 3: Layer the Meats
Arrange the slices of Genoa salami, pepperoni, and roasted turkey breast evenly over the mayo. Distributing them well is crucial so that every bite gets a perfect balance of smoky, spicy, and tender flavors. This layered meat combination is the heart and soul of the Italian sub.
Step 4: Add the Provolone Cheese
Lay down the semi-aged Provolone cheese slices over the meats. This cheese adds not only flavor but acts as a savory binder, holding together the different layers and introducing a sharp note that works wonderfully with the cured meats.
Step 5: Build the Vegetable and Pickle Layer
On the top half of the loaf, pile on chopped iceberg lettuce, chopped tomatoes, pickled banana peppers, and chopped Kalamata olives. This mix brings a variety of textures and tastes: crispness, juiciness, tang, and briny sharpness, each contributing to the sandwich’s refreshing complexity.
Step 6: Dress the Veggies and Add Seasoning
Drizzle 3 to 4 tablespoons of extra virgin olive oil and 2 tablespoons of red wine vinegar over the veggie layer. Then sprinkle 2 teaspoons of dried Italian seasoning on top. These final touches meld all the ingredients into a well-rounded flavor profile while preventing the sandwich from tasting dry or flat.
Step 7: Close and Slice the Sandwich
Press the two halves of the loaf together firmly but gently, making sure each filling layer is nestled in place. Slice the sandwich into six equal pieces to make serving easy and elegant. This step lets the flavors mingle and keeps everything tidy.
Step 8: Wrap and Store if Needed
If you aren’t enjoying your Italian subs right away, wrap them tightly in plastic wrap to lock in freshness and keep them from drying out. Refrigerate if you plan to serve them later—you’ll be surprised at how well the flavors hold up.
How to Serve How to Make Italian Sub Sandwiches Recipe

Garnishes
Enhancing your Italian sub sandwiches with simple garnishes like a few fresh basil leaves or extra pepperoncini on the side adds a lovely touch. These garnishes not only boost visual appeal but invite your guests to personalize their sandwich’s flavor further.
Side Dishes
Pair these subs with classic Italian-inspired sides like a crisp Caesar salad, a bowl of marinated olives, or perhaps some crispy garlic Parmesan fries. These sides complement the hearty sandwich without overpowering it, making for a balanced and satisfying meal.
Creative Ways to Present
For a fun twist, serve the Italian sub sandwiches open-faced on a platter, allowing everyone to pile on extra toppings. Alternatively, cut the sandwich into smaller finger-size sliders for parties or family gatherings—just perfect for sharing and sampling all the amazing flavors together.
Make Ahead and Storage
Storing Leftovers
Wrap any leftover sandwiches tightly in plastic or foil and store them in the refrigerator. They keep well for up to two days, and the flavors often deepen overnight. Just be mindful that the bread might absorb some moisture from the fillings, so consider wrapping part of the sandwich with parchment paper to avoid sogginess.
Freezing
Freezing Italian sub sandwiches isn’t generally recommended because the fresh vegetables can become watery when thawed. However, you can freeze the assembled meats and cheese layers separately, then add fresh veggies and dressings when ready to serve for the best texture and flavor.
Reheating
If you prefer a warm sandwich, unwrap it and heat it in a skillet or oven until the cheese melts and the bread crisps slightly. Adding fresh lettuce and pickles after reheating ensures your sub maintains its delightful freshness and crunch.
FAQs
Can I use other types of bread for this sandwich?
Absolutely! While Italian bread is classic, you can use a sturdy baguette, hoagie roll, or even a ciabatta loaf. Just make sure the bread is firm enough to hold all the fillings without getting soggy.
What can I substitute for Provolone cheese?
If you don’t have Provolone on hand, mozzarella or even a mild cheddar can work. Provolone’s slightly sharp and smoky flavor is ideal, but feel free to adapt based on your preference.
Is this sandwich suitable for meal prep?
Yes, but it’s best to prepare the components separately and assemble the sandwich the day you want to eat it. This prevents veggies from wilting and bread from becoming soggy.
Can I make this sandwich vegetarian?
You can! Skip the meats and add marinated grilled vegetables such as zucchini, eggplant, and roasted red peppers for a delicious vegetarian twist.
What drinks pair well with Italian sub sandwiches?
A crisp Italian soda, light red wine like Chianti, or even an ice-cold lager complement the sandwich nicely and enhance the dining experience.
Final Thoughts
I cannot recommend enough that you give this How to Make Italian Sub Sandwiches Recipe a try. It’s a wonderfully satisfying way to enjoy layers of Italian flavors and textures all in one hearty sandwich. Whether for a simple weeknight dinner or a festive gathering, these subs never fail to impress and delight. So grab your loaf and start layering—it’s sandwich time!
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How to Make Italian Sub Sandwiches Recipe
- Prep Time: 10 minutes
- Cook Time: 5 minutes
- Total Time: 15 minutes
- Yield: 6 servings
- Category: Sandwich
- Method: No-Cook
- Cuisine: Italian
Description
A classic Italian Sub Sandwich combining layers of Genoa salami, pepperoni, roasted turkey breast, and semi-aged Provolone cheese on a fresh Italian loaf. Topped with crisp iceberg lettuce, ripe tomatoes, tangy banana peppers, and Kalamata olives, then drizzled with extra virgin olive oil, red wine vinegar, and Italian seasoning for a flavorful and satisfying deli-style sandwich perfect for gatherings or a hearty meal.
Ingredients
Bread and Spread
- 1 large loaf Italian bread
- 1/3 cup (80 ml) mayonnaise
Meats
- 4 ounces (113 g) Genoa salami
- 4 ounces (113 g) pepperoni
- 8 ounces (227 g) roasted turkey breast
Cheese
- 6 ounces (170 g) Provolone cheese (semi-aged preferred)
Vegetables and Toppings
- 2 cups (150 g) chopped iceberg lettuce
- 1/2 cup (75 g) chopped tomatoes
- 1/4 cup (35 g) pickled sliced banana peppers (pepperoncini)
- 1/4 cup (35 g) chopped Kalamata olives
Dressings and Seasoning
- 3 to 4 tablespoons (45 – 60 ml) extra virgin olive oil
- 2 tablespoons (30 ml) red wine vinegar
- 2 teaspoons (2 g) dried Italian seasoning
Instructions
- Slice and Hollow the Bread: Slice the Italian loaf in half lengthwise using a serrated knife. Carefully scoop out some of the soft bread from the top half to make room for the fillings while maintaining the loaf’s structure. Save the removed bread for breadcrumbs if desired.
- Spread Mayonnaise: Evenly spread 1/3 cup (80 ml) mayonnaise on the bottom half of the loaf to add creaminess and moisture to the sandwich base.
- Layer the Meats: Arrange 4 ounces (113 g) Genoa salami, 4 ounces (113 g) pepperoni, and 8 ounces (227 g) roasted turkey breast evenly over the mayonnaise layer. Distribute the meats evenly to prevent slipping and to ensure balanced flavors in every bite.
- Add Cheese: Layer 6 ounces (170 g) semi-aged Provolone cheese slices on top of the meats. The cheese helps bind the meats and adds a distinct sharpness.
- Add Vegetables and Toppings: Place 2 cups (150 g) chopped iceberg lettuce, 1/2 cup (75 g) chopped tomatoes, 1/4 cup (35 g) pickled sliced banana peppers, and 1/4 cup (35 g) chopped Kalamata olives on the top half of the loaf for crunch, acidity, and brininess.
- Drizzle Dressing and Season: Evenly drizzle 3 to 4 tablespoons (45 – 60 ml) extra virgin olive oil and 2 tablespoons (30 ml) red wine vinegar over the vegetable layer. Sprinkle 2 teaspoons (2 g) dried Italian seasoning on top to meld flavors and prevent dryness.
- Assemble and Slice: Firmly press the two halves of the loaf together to meld the flavors and keep ingredients in place. Slice into six equal pieces for serving.
- Store Properly: If not serving immediately, wrap the sandwiches tightly in plastic wrap to maintain freshness and prevent drying. Refrigerate if storing for later use.
Notes
- Use a serrated knife for clean, even slicing of the bread loaf.
- For extra flavor, allow the sandwich to rest for 15 minutes before serving to meld the flavors.
- You can substitute Provolone with other semi-hard cheeses like mozzarella or Swiss if preferred.
- Customization: Feel free to add other vegetables such as sliced onions or cucumbers according to taste.
- Leftover bread scooped from the loaf can be dried and used as breadcrumbs for other recipes.
- Wrap sandwiches tightly if preparing ahead to retain moisture and texture.


