If you love the juicy, comforting flavors of a classic cheeseburger but want something a little lighter and more wholesome, you are going to adore this Cheeseburger Casserole with Spaghetti Squash Recipe. It’s an exciting twist on your favorite fast-food indulgence, swapped out with tender strands of spaghetti squash for a nutritious, textured base. Packed with seasoned ground turkey, tangy pickles, and that unbeatable melty cheddar cheese topping, this casserole brings all the burger magic into one cozy, baked dish that’s perfect for family dinners or meal prepping. You’ll find this recipe a delightful way to enjoy familiar flavors while sneaking in some extra veggies without feeling like you’re missing out.

Cheeseburger Casserole with Spaghetti Squash Recipe - Recipe Image

Ingredients You’ll Need

Gathering these straightforward and fresh ingredients is half the fun, and each one plays an essential role in building the flavor and texture that make the cheeseburger casserole so irresistible. From the light, stringy spaghetti squash to the rich combination of yogurt and ketchup, every component harmonizes beautifully in the final bake.

950g cooked spaghetti squash: Serves as the nutritious, low-carb “noodle” base that soaks up all the cheesy, saucy goodness.
1 tablespoon olive oil: Adds a subtle fruitiness and helps soften the aromatics when cooking.
½ yellow onion, diced: Provides a sweet and savory foundation to amp up the flavor of the meat.
1 lb ground turkey (93/7 lean): A lean protein alternative to beef, keeping the casserole hearty but lighter.
1 teaspoon salt: Essential for enhancing every layer of flavor in the dish.
½ teaspoon black pepper: Adds mild heat and depth to the meat mixture.
2 cloves garlic, minced: Infuses wonderful aroma and a touch of pungency.
½ cup ketchup: Brings the classic tangy sweetness found in cheeseburgers.
¼ cup mustard: Introduces a zesty kick to balance richness.
¼ cup nonfat plain Greek yogurt: Gives creaminess and a slight tartness while keeping it lean.
½ cup chopped pickles: The secret punch of acidity and crunch to mimic the beloved burger toppings.
1 cup shredded lite cheddar cheese, divided: Melts over the casserole for that irresistible bubbly, cheesy crust.
3 large eggs: Acts as a binder, keeping everything nicely set and cohesive when baked.

How to Make Cheeseburger Casserole with Spaghetti Squash Recipe

Step 1: Prepare the Spaghetti Squash

Begin by preheating your oven to 400°F (200°C) and greasing your 9×9 inch baking dish. Cook the spaghetti squash until tender by your preferred method — whether roasting halves cut side down or microwaving until the strands easily separate. Once cooked, use a fork to shred the flesh into long spaghetti-like strands that will serve as the perfect low-carb foundation for your casserole.

Step 2: Cook the Aromatics and Turkey

Heat olive oil in a skillet over medium-high heat, then gently soften the diced onion. Once translucent and fragrant, add the ground turkey along with salt, pepper, and minced garlic. Cook everything together until the turkey is browned and crumbly. This step develops the rich, meaty flavor that is essential for that classic cheeseburger taste without the bun.

Step 3: Combine the Key Flavor Components

In a large mixing bowl, bring together the cooked spaghetti squash, browned turkey mixture, ketchup, mustard, Greek yogurt, and chopped pickles. Each ingredient complements the others by balancing savory, tangy, and creamy textures that merge perfectly in the final bake.

Step 4: Add Eggs and Cheese

In a separate bowl, whisk the eggs until smooth. Stir half of the shredded cheddar cheese into your squash and meat mixture, then pour the whisked eggs into the same bowl. Mix everything thoroughly to ensure the cheese and eggs bind the casserole filling nicely and embed flavors evenly.

Step 5: Assemble and Bake

Transfer the combined mixture into your prepared baking dish, spreading it out evenly. Sprinkle the remaining shredded cheddar cheese on top for that signature golden and bubbly crust. Bake in the oven for one hour, or until the casserole is set firmly in the center and beautifully golden on top.

Step 6: Rest Before Serving

Remove the casserole from the oven and allow it to cool for about 15 minutes. This resting time helps the dish set further, making it easier to slice and enhancing the flavors as they meld together. The anticipation will be worth every delicious bite!

How to Serve Cheeseburger Casserole with Spaghetti Squash Recipe

Garnishes

Consider topping your casserole with fresh chopped parsley or chives to add a burst of color and freshness. You can also add a dollop of sour cream or a drizzle of extra mustard if you love that tangy edge. These garnishes brighten the dish and give it a restaurant-quality touch.

Side Dishes

This casserole pairs beautifully with a crisp green salad for contrast or some steamed green beans for a vegetable boost. If you want to keep the meal light, a side of roasted Brussels sprouts or a refreshing cucumber salad would complement the rich flavors wonderfully.

Creative Ways to Present

For casual gatherings, serve the casserole in individual ramekins to make it feel extra special. Alternatively, layer it with sliced tomatoes and pickles on the side to mimic the classic burger experience visually. Even wrapping individual portions in lettuce leaves to make “cheeseburger wraps” is a fun, creative way to enjoy this recipe.

Make Ahead and Storage

Storing Leftovers

You can store any leftover cheeseburger casserole in an airtight container in the refrigerator for up to 4 days. Make sure it’s cooled completely before sealing to retain its flavor and texture. It reheats wonderfully without losing that cheesy, savory charm.

Freezing

This recipe freezes well if you want to prepare it ahead for busy weeks. Portion it into freezer-safe containers and freeze for up to 3 months. Thaw in the refrigerator overnight before reheating to ensure the best texture and flavor.

Reheating

Reheat individual servings in the microwave for 2 to 3 minutes or until hot throughout. For a crispier top, reheat the casserole in a 350°F oven for 15 to 20 minutes. This brings back the fresh-baked appeal and keeps the cheese melty and delicious.

FAQs

Can I use ground beef instead of ground turkey?

Absolutely! Ground beef makes the dish slightly richer and more traditional in flavor. If you prefer a leaner option, turkey is perfect, but beef will give you that classic cheeseburger taste.

How do I cook spaghetti squash quickly?

The fastest method is microwaving: poke a few holes in the squash, microwave on high for about 10 to 12 minutes, then shred. Roasting takes longer but develops a nuttier flavor and firmer texture.

Is this recipe suitable for meal prep?

Definitely! This casserole stores well and reheats beautifully, making it a fantastic make-ahead option for lunches or dinners throughout the week.

Can I make this recipe dairy-free?

You can substitute the cheddar cheese with a dairy-free alternative and swap Greek yogurt for a plant-based yogurt to make it suitable for those avoiding dairy.

What if I don’t like pickles?

If pickles aren’t your thing, you can reduce the amount or swap them for chopped sautéed mushrooms or roasted red peppers for a different but still flavorful twist.

Final Thoughts

This Cheeseburger Casserole with Spaghetti Squash Recipe is a fantastic way to enjoy the flavors you love in a fun, nourishing new form. Its combination of wholesome ingredients, comforting textures, and crowd-pleasing taste make it a recipe you’ll want to keep coming back to. Give it a try and watch cheesy, tender goodness steal the show at your next meal!