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In addition to other medicinal products known to cause hyperkalaemia concomitant use of trimethoprim with spironolactone may result in clinically relevant hyperkalaemia. Immune system disorders Very rare:
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Increased antifolate effect when trimethoprim is given with pyrimethamine. Care should be taken to avoid accumulation and resulting adverse hepatological effect. Cholestatic jaundice and hepatic necrosis may be fatal. Common side effects The most common side effects with trimethoprim are itching or a mild rash.
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How to cope with side effects What to do about: Depression of haematopoiesis by trimethoprim can be counteracted by intramuscular injections of calcium folinate. Treatment may continue for at least 6 months for preventing UTIs or as a treatment for acne.
Trimethoprim may induce folate deficiency in patients predisposed to folate deficiency such as those receiving concomitant folate antagonists or anticonvulsants. Other side effects of trimethoprim are: Everyday painkillers, such as paracetamol and ibuprofenare safe to take with trimethoprim. Megaloblastic anaemia and other blooddyscrasias.
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How and when to take it Trimethoprim is usually taken twice a day to treat an infection - once in the morning and once in the evening. Plasma concentrations of trimethoprim and dapsone may increase when taken together.
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Side effects may include itching or a mild skin rash, but these are usually mild and short-lived. If you stop your treatment early, your problem could come back. Trimethoprim increases plasma concentrations of procainamide. For more information about how trimethoprim can affect you and your baby during pregnancy, read this leaflet on the Best Use of Medicines BUMPS website.
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